|10 mg||5 vials and 1 vial of diluent|
|Description||RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) used as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth.|
|Chemical name||4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl) benzonitrile|
|Synonyms||154992-24-2 RU 58841 RU58841 RU-58841 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl) benzonitrile|
|MeSH Entry Terms||4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxybutyl)-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile Benzonitrile, 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)- RU 58841 RU-58841 RU58841|
|Chemical and physical data|
|Molecular Weight||369.344 g·mol−1|
|Melting point||103.5-104.2° C|
|Boiling point||493.6±55.0 °C at 760 mmHg|
|Vapour Pressure||0.0±1.3 mmHg at 25°C|
|Enthalpy of Vaporization||80.1±3.0 kJ/mol|
|Index of Refraction||1.560|
|Molar Refractivity||85.5±0.4 cm3|
|Flash Point||252.3±31.5 °C|
|Solubility||≥36.9 mg/mL in DMSO, ≥87.6 mg/mL in EtOH,insoluble in H2O|
|Polar Surface Area||85 Å2|
|Surface Tension||55.2±5.0 dyne/cm|
|Molar Volume||264.4±5.0 cm3|
|IUPAC name||4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl) benzonitrile|
|InChI||1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26) 22(16)7-3 -4-8-24) 12-6-5-11( 10-21)13(9-1 2)17 (18,19)20/ h5-6,9,24H,3-4,7-8H2,1-2H3|
|DSSTox Substance ID||DTXSID20165781|
|Smiles||CC1(C(=O)N(C(=O)N 1CCCCO)C2=CC(= C(C=C2)C# N)C(F)(F)F) C|
|Canonical SMILES||CC1(C(=O)N(C(=O)N 1CCCCO)C2=CC (=C(C=C2)C #N)C(F)(F) F)C|
All products listed through CanadaPeptides.co are intended for research purposes only, The information contained in this website is provided “as is” and is for general information purposes only and is not intended for use in food products or as any type of drug and not intended to treat, prevent, mitigate or cure any disease or medical condition and are for research purposes only. This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. These product are NOT for use as food additives, drugs, cosmetic, household chemicals, or other inappropriate applications.
YOU MUST BE A MINIMUM OF 21 YEARS OF AGE.
The listing of a material on this website does not constitute a license to, or a recommendation for its use in infringement of any patent. All of the products will be handled only by qualified and trained individuals. Under NO circumstances shall/should ANY of these materials be used for but not limited to: in vitro diagnostic, foods, drugs, medical devices, cosmetics, commercial purposes, any general consumptive purpose, and animal and/or human use. All customers are ASSUMED to be legal researchers or licensed researchers.
IF you or your affiliates are NOT then WE DO NOT KNOW THIS and you will be held liable for FRAUD/DECEIT.
Research Chemicals and Peptides: Harmful if swallowed. Irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water. During research wear suitable protective clothing and gloves. Keep unprotected persons away. For use only by qualified researchers. Water hazardous. Research in a well ventilated area. Do not breathe dust, vapor, mist or gas. Do not ingest or inhale. Use safety glasses face protection. Disposal must be made according to official regulations. Wash hands after handling. Store in a cool dry place. Usual precautionary measures should be adhered to in handling the chemicals & peptides.
RECOMMENDATIONS FOR SOLUBILIZATION OF PEPTIDES
Start with an appropriate choice of solvent that is both compatible with your experimental procedures and that does not react with or degrade the peptide. The solvent should be dry and degassed. Since most peptide work is small-scale, it is most practical to buy small volumes of dry solvent, rather than attempting to dry it yourself. Determine whether the peptide is acidic, basic or neutral and proceed with solubilization using a small amount of the peptide. Acidic and basic peptides are more soluble at neutral pH than acidic pH.
Peptides are acidic when the manufacturing process is complete, due to the presence of trifluoroacetate (TFA) as the counter ion (a result of the cleavage or purification process). Check whether the peptide is supplied as a TFA salt before you start the purification process.
Short non-hydrophobic peptides (less than 5 amino acids) and peptides containing >25% non-clustered, charged residues and <25% hydrophobic residues will typically dissolve in aqueous solutions.
Simply adding water may dissolve basic peptides. If it does not, first try a drop (10-20 µl) of glacial acetic acid and sonicate or vortex. This may be increased up to 30% acetic acid by volume for problematic sequences. Addition of base can also promote oxidation of cysteines to the disulphide so deoxygenated buffers should always be used. For basic peptides with net charge of +1 or greater, an acidic solution will be needed.
Acidic peptides with net charge of -1 or greater should be dissolved in a small amount of basic solvent such as 0.1% ammonium hydroxide or ammonium bicarbonate and diluted to the required stock concentration with water. The exception is peptides containing Cys, as disulphide bonds may form at alkaline pH.
Neutral or hydrophobic peptides with a net charge of zero can sometimes be brought into solution by addition of base, but often a gel forms. Generally this gel will only respond to dilution with higher amounts of distilled, deionized water, along with sonication and vortexing.
Peptides that are >50% hydrophobic may be difficult to dissolve in water alone and should be dissolved in a small amount of organic solvent, for example acetonitrile, methanol, isopropanol, dimethyl suphoxide (DMSO), dimethylformamide (DMF). This should be added drop wise, followed by sonication and vortexing after every drop until the peptide dissolves. The drop wise addition of the organic solvent can also be used for peptides that do not respond to pH adjustment. Note that some cell culture based assays may not react well to DMSO, so a different solvent should be considered.
Peptides that are >75% hydrophobic are unlikely to dissolve in aqueous solution alone and may require solubilization in a stronger solvent such as TFA or formic acid and at high concentration. The peptide may precipitate out when aqueous buffer is added. These conditions may not be compatible with some cell culture based experiments.
Organic solvents at certain concentrations are incompatible with some biochemical assays. A small amount of DMSO should be compatible with most immunological assays, but avoid DMSO if the peptide contains Methionine, Cysteine or Tryptophan due to sulphoxide or disulphide formation. These peptides should be prepared using 1,2-ethanediol (EDT) or dithiothreitol (DTT) in order to prevent oxidation. Oxygen-free water or buffers, or DTT are recommended for solubilizaton.Note, if DMSO solvent is at all wet it will not freeze at -20°C, so freezing at -30°C is recommended. DMSO is hygroscopic and will adsorb water if subjected to repeated freeze-thaw cycles. To minimize these issues, buy small volumes of dry DMSO for solubilzation purposes.
Peptides that are prone to aggregation may require strong denaturants (e.g., 6M urea or guanidine hydrochloride), which may then be able to be diluted.
If peptides are to be used in cellular assays, start by making a concentrated stock solution e.g., 5-10 mM, or 5-10mg/ml. Dilute the peptides into physiological buffer for use, such that the original solvent is present at no more than 0.1% in the final working solution. Diluted peptide solutions may also be filter-sterilized (0.22mm) if they are to be added to sterile cultures.
Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.
WARNING! LABORATORY RESEARCH USE ONLY.
For research/laboratory in vitro use
Only Laboratory Reagents
NOT for Human
NOT for Animals
NOT for Diagnostic
We strongly recommend that you follow these guidelines to ensure that substances retain their quality and potency.
Storage of Reconstituted Peptides
ALWAYS allow peptides to come to room temperature before reconstituting with water. This will avoid most cases of peptides becoming cloudy.
Allow peptides to warm to room temperature before opening the vial to prevent condensation of atmospheric moisture onto the peptide, making it easier to handle and weigh. It is recommended to dissolve only the required amount into a buffer. The remainder of the stock should be stored dry at -20°C.
Once the peptides have been mixed or reconstituted into a liquid solution they must be refrigerated at a temperature of between 2-8c. If stored at room temperature they may begin to degrade after as little as 24 hours. Therefore we recommend storing them in the fridge as soon as possible after mixing. Stored in the fridge they will remain potent for around 8 weeks before beginning to degrade. Do not shake peptides aggressively as this can ruin them. Store peptides in sealed containers away from food.
Storage in buffer is not recommended. Peptides in solution are only stable for up to one week when stored at 4°C.
Storage of Lyophilised (freeze-dried) Peptides
The peptides we sell come in a lyophilised, freeze-dried form. Like this, the peptides will remain stable for around 30 days at room temperature. If there not going to be used within this time then they must be stored in a freezer at a temperature of around -20c where they will remain stable for approximately 48 months.
If peptides are to be used frequently, solubilize and aliquot, then store frozen at -20°C to avoid freeze-thaw cycles. Typically the peptide will remain stable for several months.
For short term storage (up to 2 months), freeze at -20°C; for long term storage -80°C is recommended.
Ideally, vials for peptide storage should be high-density, polypropylene tubes, airtight, well-sealed with a screw cap with an O-ring. Avoid storing or making up peptide solutions in polystyrene containers as they adsorb peptide material to their surface.
Peptides containing Cys, Trp or Met are susceptible to oxidation. It is advisable to blanket the peptide with argon or nitrogen when the vial is opened. Buffers used to dissolve these peptides should be degassed. These peptides have limited stability; long-term storage is not recommended.
Hygroscopic peptides containing several charged residues (D, E, K, R, H) may take up water when exposed to air. To prevent this, argon or nitrogen may be used to blanket the peptide when the vial is opened. If inert gases are unavailable, then storage in a desiccator is a viable alternative. Before use, bring samples to room temperature in a desiccator.
Please ensure that your freezer is not ‘frost free’ or ‘auto defrosting’ as constant freeze/thaw cycles will degrade the peptides over time.
Scientific & Educational
Terms & Conditions
GENERAL TERMS AND CONDITIONS OF USE AGREEMENT
All customers MUST be at least 21 years of age to enter this web site
IF YOU ARE UNDER 21 YEARS OF AGE, IT IS UNLAWFUL FOR YOU TO VISIT, READ, OR INTERACT WITH THIS WEBSITE OR ITS CONTENTS IN ANY MANNER. THIS WEBSITE SPECIFICALLY DENIES ACCESS TO ANY INDIVIDUAL THAT IS COVERED BY THE CHILD ONLINE PRIVACY ACT
Thank you for visiting Canada Peptides (the Web Site).
PLEASE READ AND REVIEW THE FOLLOWING TERMS AND CONDITIONS OF USE AGREEMENT CAREFULLY EACH TIME BEFORE USING THIS WEBSITE.
The information contained in this website is provided “as is” and is for general information purposes only.
This web site is not an online shop.
CanadaPeptides.co does not allow visitors from countries, which classify products displayed at our website as special controlled or scheduled substances, including but not limited to the United States, Australia, Canada, Panama and European Union; does not sell any products online; does not sale to the public; does not ship any products; does not directly or indirectly associated with any websites that may engage in selling same or similar products. Canada Peptide Material must be used exclusively for scientific research purposes. The chemicals/materials are not for sale here are SOLELY intended for Laboratory and research educational purposes only. Purposes NOT intended for products include, but not limited to: in vitro diagnostic, foods, drugs, medical devices, cosmetics, commercial purposes, any general consumptive purpose, and animal and/or human use. Visitors of the website acknowledge that the products have NOT been tested by supplier for safety and efficiency or efficacy in food, drug and medical device cosmetic commercial or any other use.
The content is for informational purposes only and is not intended to provide specific advice for you, and should not be relied upon in that regard.
Materials presented here are strictly for Academic and\or Laboratory Educational Research Purposes. By using this Web Site, you agree to these Terms and Conditions of Use Agreement.
The information is provided by Canada Peptides, and while we endeavor to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.
If you do not agree, please exit and disregard the information contained herein.
Canada Peptides reserves the right to change this Terms and Conditions of Use Agreement, in whole or in part, at any time without prior notice to you.
Accordingly, you should always review this disclaimer prior to using this Web Site in order to ensure that you understand the terms under which you are permitted access.
Your Use of Our Web Site Unless specified otherwise, your use of this Web Site is governed by this Terms and Conditions of Use Agreement.
In using this Web Site, you are prohibited from modifying, distributing, transmitting, reproducing, publishing, licensing, transferring, or selling any information, products or services obtained or viewed on this Web Site. However, you may display, download, or print hard copies of any material contained on this Web Site for your own personal, non-commercial use as long as you do not modify the content. Any other use of the information contained on this Web Site is prohibited without our express written consent. Use of Information This Web site provides information that, while useful, must not be used as a substitute for the advice of your own advisor’s. Information available from this Web Site is not intended to be used to diagnose any medical condition or disease.
Visitor has no rights whatsoever to use the content of, or portions thereof, including its databases, invisible pages, linked pages, underlying code, or other intellectual property the site may contain, for any reason for any use whatsoever. Nothing.
Visitor agrees to liquidated damages in the amount of U.S.$100000000 in addition to costs and actual damages for breach of this provision. Visitor warrants that he or she understands that accepting this provision is a condition of viewing and that viewing constitutes acceptance.
Products on this website are general information and education or for research purposes only.
Canada Peptides reserves the right to correct any inaccuracies or typographical errors in the information posted on this Web Site, and shall have no liability for such errors. Information may be changed or updated without notice.
Not Offering Any Advice
The content is for informational purposes only and is not intended to provide specific advice for you, and should not be relied upon in that regard. You should not act or rely on the content without seeking the advice of a professional. Links/Software Links from or to websites outside this Web Site are meant for convenience only. Canada Peptides does not review, endorse, approve or control, and is not responsible for any sites linked from or to this Web Site, the content of those sites, the third parties named therein, or their products or services. Linking to any other site is at your sole risk and Canada Peptides will not be responsible or liable for any damages in connection with linking.
Canada Peptides disclaims all warranties, express and implied as to the accuracy, validity and legality of any materials or information found on those sites.
Links to downloadable software sites are for convenience only and Canada Peptides is not responsible or liable for any difficulties or consequences associated with downloading the software. Use of any downloaded software is governed by the terms of the license agreement, if any, which accompanies or is provided with the software.
This Web Site is generally available to users Twenty-four (24) hours per day, Seven (7) days per week, Three Hundred Sixty-five (365) days per year. However, Canada Peptides retains the right to make our Web Site unavailable at any time, for any reason, and for any length of time. By using this Web Site you agree that Canada Peptides will not be liable for any damage arising out of or related to any such interruption, suspension, or termination of this Web Site and/or the services or products contained therein.
THIS WEB SITE CANNOT AND DOES NOT, CONTAIN INFORMATION ABOUT ALL APPLICATIONS FOR PRODUCTS PRESENTED HERE. IT MAY NOT CONTAIN ALL INFORMATION THAT IS APPLICABLE. THE CONTENT OF THIS WEB SITE, THE WEB SITE SERVER THAT MAKES IT AVAILABLE, AND THE SERVICES AND PRODUCTS CANADA PEPTIDES PROVIDES ON THIS WEB SITE, ARE PROVIDED ON AN “AS IS” AND FOR INFORMATIVE BASIS WITHOUT WARRANTY OF ANY KIND, WHETHER EXPRESS, IMPLIED OR STATUTORY.
CANADA PEPTIDES EXPRESSLY DISCLAIMS LIABILITY FOR TECHNICAL FAILURES (INCLUDING HARDWARE OR SOFTWARE FAILURES), INCOMPLETE, SCRAMBLED OR DELAYED COMPUTER TRANSMISSIONS, AND/OR TECHNICAL INACCURACIES, AS WELL AS UNAUTHORIZED ACCESS OF USER TRANSMISSIONS BY THIRD PARTIES. FURTHER, CANADA PEPTIDES DOES NOT REPRESENT OR WARRANT THAT NO VIRUSES OR OTHER CONTAMINATING OR DESTRUCTIVE PROPERTIES WILL BE TRANSMITTED, OR THAT NO DAMAGE WILL OCCUR TO YOUR COMPUTER SYSTEM. YOU HAVE SOLE RESPONSIBILITY FOR ADEQUATE PROTECTION AND BACKUP OF DATA AND/OR EQUIPMENT AND TO TAKE ALL PRECAUTIONS TO SCAN FOR COMPUTER VIRUSES OR OTHER DESTRUCTIVE PROPERTIES.
BY YOUR USE OF THIS WEBSITE, YOU ACKNOWLEDGE THAT SUCH USE IS AT YOUR SOLE RISK, INCLUDING RESPONSIBILITY FOR ALL COSTS ASSOCIATED WITH ALL NECESSARY SERVICING OR REPAIRS OF ANY EQUIPMENT YOU USE IN CONNECTION WITH THIS WEBSITE.
Description of products we display at our website are intended for laboratory research use only. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. They are not for sale.
By agreeing to aforementioned and subsequent acknowledgement of remainder of said disclaimer, you are affirming that you are, the equivalent or of greater academic certification, a Laboratory Technologist or Technician.
Upon acceptance of these terms and conditions of use Canada Peptides authorizes you to view the Content on the Web Site solely for your educational purposes only.
By clicking “I agree” you agree with this disclaimer Policy.
Thank you for your cooperation